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Your Health Where It Belongs... Your Hands

COMT Individual Gene-Cell Science Systems Kit:

Note: This is a test kit that will be mailed to you. It can be performed using a swab or a blood draw. Unless we are told otherwise, the swabs will be sent to you. It is your responsibility to arrange for the blood draw for your kit should you choose the blood draw.


Fasting Required: No
Lab: Cell Science Systems
Specimen: Swab (Blood - by request only)
Results: Average processing time 10-15 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Medication and Supplement Instructions for CSS Testing:
  • Testing does not need to be delayed because of medication or supplement use.
  • Medications that are part of your daily routine should be continued as they are considered part of your normal physiological state.
  • If possible, please avoid taking any oral medications, IV infusions, intramuscular (IM) injections, or oral supplements for 4 hours before blood draw.
  • If you are taking medications that may impact white blood cell counts, it is recommended to collect an additional blood tube at the time of your draw.
  • For short term medications (such as antibiotics) that will be discontinued, it is best to wait at least 2 weeks after completing the medication before completing your blood draw.
  • If you are taking methylene blue, it is recommended to wait at least 72 hours after your last dose before proceeding with your blood draw for the Cellular Nutrition Assay.
  • Fasting is not necessary


Description: COMT is the major enzyme involved in the methylation process. COMT catalyzes the transfer of the functional methyl group from S-adenosyl methionine (SAMe) to a substrate, which has to be methylated. Two SNPs, Val108/158Met and Ala52/102Thr, are known to alter COMT methylation capacity.

These 2 SNPs of the COMT gene are associated in literature with: Impaired DNA methylation, Impaired neurotransmitter metabolism, Decreased drug metabolism (important in neurodegenerative disorders), Decreased detoxification of toxic catecholamines from the environment, Involvement in the manifestation of a variety of human disorders, including estrogen induced cancers, Parkinson’s disease, depression, and hypertension.