Your Health Where It Belongs... Your Hands

Note: This is a test kit that will be mailed to you. It requires a blood draw. It is your responsibility to arrange the blood draw for your kit and payment of your specimen collection.

Fasting Required: No
Lab: Diagnostic Solutions
Specimen: Blood
Results: Average processing time 10-12 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Special Instructions: Ship frozen specimen to lab Monday-Thursday only. DO NOT discontinue and medications unless directed by your physician.

Description: Cytokines are signaling proteins that regulate communication between immune cells and coordinate inflammatory and immune responses throughout the body. They play essential roles in host defense, tissue repair, and immune system regulation. When cytokine activity becomes dysregulated, immune tolerance and inflammatory balance may be disrupted, potentially contributing to autoimmune activity, chronic inflammatory conditions, allergic responses, and multisystem symptom presentations.

Cytokines help regulate both innate and adaptive immune responses. Measuring cytokine activity may provide clinically relevant insight into inflammatory pathways, immune signaling, and T-cell response patterns. The CytoDx Cytokine Response Profile evaluates cytokines associated with:

• Inflammatory signaling
• Th1, Th2, and Th17 immune responses
• Treg immune tolerance
• Autoimmune and chronic inflammatory pathways
• Allergic and mucosal immune responses
• Innate and adaptive immune coordination

Cytokine Categories Evaluated by CytoDx: The CytoDx Cytokine Response Profile evaluates cytokines associated with: Acute Inflammation associated with early inflammatory signaling, innate immune activation, and acute tissue response.

• GM-CSF
• IL-1a
• IL-1ß
• IL-6
• TNF-a

Adaptive Immune Activity TH1, associated with viral and bacterial defense, macrophage activation, and cellular immune responses.

• IFN-?
• IL-2
• IL-15
• TNF-ß
• IL-12p70
• IL-12/23p40 (Th1/Th17)

Th17, associated with mucosal and gut barrier defense, gut and skin immune responses.

• IL-17A
  IL-12/23p40 (Th1/Th17)
  Th2, associated with allergic responses, IgE signaling, eosinophil activation, and anti-parasitic immune activity.
  • IL-4
  • IL-5
  • IL-13
  Other, Chemoattractant associated with T cell recruitment.
  • IL-7
  
  Anti-Inflammatory / Regulatory / Immune Tolerance Associated with immune tolerance, immune modulation, and resolution of inflammatory activity.
  • IL-10
  • IL-16
  
  Chemokines Involved in chemokine signaling and immune cell trafficking to sites of inflammation and tissue activity.
  • Eotaxin (CCL11)
  • Eotaxin-3 (CCL26)
  • IL-8 (CXCL8)
  • IP-10 (CXCL10)
  • MCP (CCL2)
  • MCP-4 (CCL13)
  • MDC (CCL22)
  • MIP-1a (CCL3)
  • MIP-1ß (CCL4)
  • TARC (CCL17)
  • RANTES (CCL5)
  
  Angiogenesis Associated with vascular remodeling, tissue repair, and angiogenic signaling.
  • bFGF
  • sFLT-1
  • PIGF
  • Tie-2
  • VEGF-A
  • VEGF-C
  • VEGF-D
  
  Vascular Injury Associated with vascular inflammation, endothelial activation, and tissue injury responses.
  • CRP
  • sICAM-1
  • SAA
  • sVCAM-1