Histamine Intolerance-Cell Science Systems Kit:
Note: This is a test kit that will be mailed to you. It requires a blood draw. It is your responsibility to arrange the blood draw for your kit and payment of your specimen collection.
Fasting Required: No
Lab: Cell Science Systems
Specimen: Blood
Results: Average processing time 5-7 business days once the lab receives the specimen
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.
Medication and Supplement Instructions for CSS Testing:
- Testing does not need to be delayed because of medication or supplement use.
- Medications that are part of your daily routine should be continued as they are considered part of your normal physiological state.
- If possible, please avoid taking any oral medications, IV infusions, intramuscular (IM) injections, or oral supplements for 4 hours before blood draw.
- If you are taking medications that may impact white blood cell counts, it is recommended to collect an additional blood tube at the time of your draw.
- For short term medications (such as antibiotics) that will be discontinued, it is best to wait at least 2 weeks after completing the medication before completing your blood draw.
- If you are taking methylene blue, it is recommended to wait at least 72 hours after your last dose before proceeding with your blood draw for the Cellular Nutrition Assay.
- Fasting is not necessary
Description: Histamine is a natural substance found both in the body and in various foods. It plays an important role in immune function, digestion, and the nervous system. In the body, histamine helps fight infections, regulates stomach acid, and acts as a chemical messenger in the brain. It is stored in certain white blood cells, such as mast cells and basophils, and released when the body perceives a threat, such as an allergy or injury. In addition to being produced internally, histamine is also present in many foods, particularly aged, fermented, and processed foods.
The body maintains histamine balance through specialized enzymes that break it down and clear it from circulation. These enzymes work in different locations to ensure histamine levels do not become excessive. • DAO (Diamine Oxidase): Breaks down histamine in the gut before absorption. • HNMT (Histamine N-Methyltransferase): Degrades histamine inside cells, particularly in the liver and brain. • ALDH (Aldehyde Dehydrogenase): Helps clear histamine breakdown products. If these enzymes do not work properly, histamine builds up.
Histamine intolerance can be challenging to identify because symptoms mimic allergies and other food sensitivities. Traditional methods of assessment include symptom history, dietary trials, and blood testing for enzyme levels, but these approaches often lack precision. The Cell Science Systems, Histamine Intolerance Test, provides a more personalized approach by analyzing genetic variants in the DAO (AOC1) gene, which plays a critical role in breaking down histamine in the gut. By assessing genetic risk alongside symptom patterns, this test helps identify individuals who may have a reduced ability to process dietary histamine, allowing for more targeted dietary and lifestyle recommendations. With a scientific, genetics-based approach, this test provides valuable insight into whether genetic factors contribute to histamine intolerance, helping both patients and practitioners make informed decisions for effective symptom management.
Includes Genetic Markers for Histamine Intolerance:
- C47T (rs10156191)
- C995T (rs1049742)
- C1990G (rs1049793)
- G691T (rs2052129)