Metabolomix+ - Genova Kit:
Note: This is a home collection test kit that will be mailed to you.
Fasting Required: No
Specimen: Urine
Lab: Genova Diagnostics
Results: Average processing time 14 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.
Special Instructions:
Testing is not available for patients less than 2 years old. Female patients should not collect during menstrual period.
2 Days before the test discontinue all of the following (unless instructed otherwise by your physician): » Supplements containing creatine, vitamin C or any mineral elements measured on this test » Other substances that may influence urinary element excretion of elements » Seafood (unless asked to continue by your healthcare provider) » Continue with the above food restrictions until your sample is completely collected
24-hrs before the test eat usual diet, but avoid over-consuming any single food or extreme diet. Fluid intake should be limited to eight (8) 8-ounce glasses of fluid over a 24 hour period
Description: The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids. Insights gained from the Metabolomix+ nutritional test allows clinicians to target nutritional therapies to the precise needs of their patients. Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect. Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels. Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm.
Traditionally, urinary organic acid assessment has been used in neonatal/pediatric medicine to identify genetic inborn errors of metabolism, with severity depending on the degree and type of error. In many cases of genetic inborn errors, the enzymatic defect may be compensated for by high doses of specific vitamin and mineral cofactors and/or dietary interventions. Intervention with higher-dose nutrient cofactors may also be effective in cases of decreased enzyme activity due to causes other than frank inborn errors.
Organic Acids
- Malabsorption and Dysbiosis
- Cellular Energy and Mitochondrial Metabolites
- Neurotransmitter Metabolites
- Vitamin Markers
- Toxin and Detoxification Markers
- Tyrosine Metabolism
Amino Acids
- Nutritionally Essential Amino Acids
- Nonessential Protein Amino Acids
- Intermediary Metabolites
- Dietary Peptide Related Markers
Oxidative Stress Markers
Essential and Metabolic Fatty Acids - Bloodspot (if selected as an add-on)
- Omega 3 Fatty Acids
- Omega 6 Fatty Acids
- Omega 9 Fatty Acids
- Saturated Fatty Acids
- Monounsaturated Fatty Acids
- Delta-6 Desaturase Activity
- Cardiovascular Risk
Additional Biomarkers Available for add-on at additional cost:
- MTHFR (C677T & A1298C)
- COMT (V158M)
- APOE
- TNF-a
Toxic Element Clearance Profile or Comprehensive Urine Elements can be ordered as an add-on. Both cannot be ordered at the same time.
Toxic Element Clearance Profile (if selected as an add-on at an additional cost)
- Aluminum
- Antimony
- Arsenic
- Barium
- Bismuth
- Cadmium
- Cesium
- Creatinine
- Gadolinium
- Gallium
- Lead
- Mercury
- Nickel
- Niobium
- Platinum
- Rubidium
- Sulfur
- Thallium
- Thorium
- Tin
- Tungsten
- Uranium
Comprehensive Urine Elements (if selected as an add-on at an additional cost):
- Aluminum
- Antimony
- Arsenic
- Barium
- Bismuth
- Cadmium
- Calcium
- Cesium
- Chromium
- Cobalt
- Copper
- Creatinine
- Gadolinium
- Gallium
- Iron
- Lead
- Lithium
- Magnesium
- Manganese
- Mercury
- Molybdenum
- Nickel
- Niobium
- Platinum
- Potassium
- Rubidium
- Selenium
- Strontium
- Sulfur
- Thallium
- Thorium
- Tin
- Tungsten
- Uranium
- Vanadium
- Zinc
Additional Biomarkers Available for add-on at additional cost:
- MTHFR (C677T & A1298C)
- COMT (V158M)
- APOE
- TNF-a