MTHFR Combined (A1298C + C677T) Genomic SNP (Add-on Only)-Genova Kit:
Note: This is a test kit that will be mailed to you.
Coupon Codes not valid for Add-on testing. Fasting Required: No Lab: Genova Diagnostics Specimen: Buccal Swab **As of 5/15/2023 the turnaround time for this test is a minimum of 30 days due to excessive volume** Results: Average processing time 14-21 business days Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance. Description: This particular gene variation can impact how well your body can metabolize folate and folic acid. Both of these are forms of Vitamin B9 which are required for numerous critical bodily functions.MTHFR provides your body with instructions for making a certain enzyme called methylenetetrahydrofolate reductase or MTHFR for short.
Methylenetetrahydrofolate reductase plays a central role in converting folate into the active form that is found circulating in your blood. This form of folate is then utilized in the process of lowering homocysteine levels in your body.
Maintaining appropriate levels of homocysteine is important in the prevention of chronic diseases such as coronary artery disease (CAD), stroke, Alzheimer’s and autism. Mutations in the MTHFR gene can cause it to be less efficient in converting folate to its active form, which in turn may lead to elevated levels of homocysteine.
There are two main MTHFR mutations that researchers focus on most often. These MTHFR mutations are called polymorphisms and are referred to as C677T and A1298C. Mutations can occur on different locations of these genes and be inherited from only one or both parents. Having one mutated allele (a variant form of a given gene) is associated with increased risk of certain health conditions but having two increases the risk further.