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Protein C Activity:

Fasting Required: No
Lab: Quest Diagnostics
Specimen: Blood
Results: Test run Mon, Wed, Fri; average processing time report available in 3-5 days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Description: Protein C is a vitamin K-dependent glycoprotein that is synthesized in the liver. It circulates in an inactive form. It is activated by the thrombin-thrombomodulin complex on endothelial cells. Activated protein C degrades the activated clotting factors Va and VIIIa.

This test aids in the diagnosis of decreased activity of Protein C characterized by recurrent venous thrombosis. Acquired deficiencies associated with Protein C include: Oral anticoagulant therapy, liver disease, vitamin K deficiency, malignancy, consumptive DIC, surgery, trauma, antibodies to Protein C and hepatic immaturity of the newborn.

Alternate Name(s): Protein C Chromogenic, Protein C Functional, Functional Protein C