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Vitamin D, 1,25-Dihydroxy, LC/MS/MS (Calcitriol):

Fasting Required: No
Lab: Quest Diagnostics
Specimen: Blood
Results: Average processing time 3-5 days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Description: 1,25-Dihydroxy Vitamin D (Calcitriol) is the hormonally active metabolite of vitamin D. Calcitriol increases the level of calcium in the blood by increasing the uptake of calcium from the gut into the blood, and possibly increasing the release of calcium into the blood from bone. Levels may be high in primary hyperparathyroidism and may be decreased in hypoparathyroidism and chronic renal failure.

Serum 1,25(OH)2D does not reflect vitamin D reserves, and measurement of 1,25(OH)2D is not useful to monitor vitamin D status. Serum 1,25(OH)2D is frequently either normal or even elevated in those with vitamin D deficiency, because of secondary hyperparathyroidism. Thus, 1,25(OH)2D measurement does not reflect vitamin D status. Measurement of 1,25(OH)2D is useful only for patients with disorders of 25(OH)D and phosphate metabolism. These include chronic kidney disease, hereditary phosphate-losing disorders, oncogenic osteomalacia, pseudovitamin D-deficiency rickets, vitamin D-resistant rickets, and chronic granuloma-forming disorders, such as sarcoidosis and some lymphomas.

Includes: Vitamin D,1,25 (OH)2, Total; Vitamin D3, 1,25 (OH)2; Vitamin D2, 1,25 (OH)2